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Trial-to-condition map

Matrix view mapping each registered clinical trial to the conditions it addresses. Each cell shows the trial's evidence grade where an explicit cross-link exists in the trial registry. Blank cells indicate no explicit cross-link, not a proof of absence.

By Metabolic Peptides Editorial TeamReviewed by Scientific Review PanelLast updated
TrialMolecule / PhaseType 2 diabetesObesityPrediabetesMetabolic syndromeMASLD / MASH (metabolic dysfunction-associated steatotic liver disease)Obstructive sleep apnoea (OSA)Heart failure with preserved ejection fraction (HFpEF)Cardiovascular riskChronic kidney disease (CKD)HIV-associated lipodystrophyVisceral adipositySarcopenic obesity and lean-mass concernsPost-weight-loss maintenanceWeight regain after GLP-1 discontinuationPolycystic ovary syndrome (PCOS)
SURMOUNT-1Tirzepatide
Phase 3
—Ph 3—————————————
SURMOUNT-2Tirzepatide
Phase 3
Ph 3Ph 3—————————————
SURMOUNT-3Tirzepatide
Phase 3
—Ph 3—————————————
SURMOUNT-4Tirzepatide
Phase 3
————————————Ph 3Ph 3—
SURMOUNT-5Tirzepatide
Phase 3
—Ph 3—————————————
SURPASS-2Tirzepatide
Phase 3
Ph 3——————————————
SURPASS-CVOTTirzepatide
Phase 3 CVOT
Outcome——————Outcome———————
SELECTSemaglutide 2.4 mg
Outcome trial
—Outcome—————Outcome———————
STEP 1Semaglutide 2.4 mg
Phase 3
—Ph 3—————————————
STEP 2Semaglutide 2.4 mg
Phase 3
Ph 3Ph 3—————————————
STEP 5Semaglutide 2.4 mg
Phase 3
—Ph 3——————————Ph 3——
LEADERLiraglutide
Outcome trial
Outcome——————Outcome———————
SUSTAIN-6Semaglutide
Outcome trial
Outcome——————Outcome———————
PIONEER 6Semaglutide (oral)
Outcome trial
Outcome——————Outcome———————
REWINDDulaglutide
Outcome trial
Outcome——————OutcomeOutcome——————
SCALE Obesity and PrediabetesLiraglutide 3.0 mg
Phase 3
—Ph 3Ph 3————————————
TRIUMPH programmeRetatrutide
Phase 3
Ph 3Ph 3——Ph 3——————————
FLOWSemaglutide 1.0 mg
Outcome trial
Outcome———————Outcome——————
SUMMITTirzepatide
Phase 3
—Outcome————Outcome————————
SYNERGY-NASHTirzepatide
Phase 3
Ph 3———Ph 3——————————

Evidence-grade legend

PreclinicalEvidence: Preclinical
Ph 1Evidence: Phase 1
Ph 2Evidence: Phase 2
Ph 3Evidence: Phase 3
OutcomeEvidence: Outcome trial evidence
LicensedEvidence: Licensed medicine evidence

Abbreviated cell labels expand to full evidence-grade badges in the legend above. Cell abbreviations: Ph 1 = Phase 1, Ph 2 = Phase 2, Ph 3 = Phase 3, Outcome = Outcome trial evidence, Licensed = Licensed medicine evidence. A dash (—) means no explicit cross-link in our trial registry.

What this map does not prove
  • Cells indicate where evidence has been reported, not endorsement of that trial's findings or suitability for any individual.
  • A single trial result does not generalise outside its studied population.
  • Blank cells mean no explicit cross-link in our trial registry, not a proof of absence of evidence elsewhere.
  • Evidence grade is the trial's overall stage, not a quality rating or measure of effect size.
Last reviewed 21 May 2026 · trial-to-condition map · Metabolic Peptides editorial team