Methodology guides
Metabolic peptide research guides
Mechanism explainers and methodology references. See also the structured /mechanisms/ hub for the canonical pathway pages and /research-methods/ for trial-reading primers.
Managing GLP-1 GI Side Effects
The GLP-1 / dual-agonist gastrointestinal profile: when it peaks, what trial data shows mitigates it, dietary and dose-hold strategies.
Managing Refractory Nausea on GLP-1
Beyond standard titration: dose-hold vs dose-reduction, switching considerations, and recognising when stopping is the right outcome.
GLP-1 Mechanism of Action
How GLP-1 receptor signalling drives appetite suppression, glycaemic control, and adipose-tissue remodelling — explained at the molecular level.
Measuring Body Composition in Research
DXA, MRI-PDFF, BIA, hydrostatic weighing: which methodology fits which research question, and the methodological cautions for metabolic peptide trials.
UK MHRA Regulation of GLP-1 Peptides
How MHRA licensing works for GLP-1 medicines: SmPC, prescription-only status, NICE technology appraisals and the UK regulatory framework.